Small molecule-induced destabilization of β-catenin and RAS is the ideal strategies for suppressing colorectal cancer
نویسندگان
چکیده
Background: Mutations of adenomatous polyposis coli (APC) and KRAS play essential roles in the development colorectal cancer (CRC) by forming an abnormal colon morphology. Despite intensive efforts to discover therapeutic strategies re-transform cells into normal cells, no effective approaches have been reported yet.Methods: In this study, we aimed identify for inducing morphological changes tumor organoids structures similar intestine ApcMin/+/KrasG12DLA2 mice using KYA1797K, a dual inhibitor Wnt/β-catenin RAS signaling pathways.Results: previously identified as pathways, inhibited growth derived from mice, with transformation benign structures, bone morphogenetic protein 4 (BMP4), intestinal differentiation inducer.Conclusion: Given anti-cancer effects KYA1797K its ability induce those elicited BMP4 treatment, suppression is potential therapy treating CRC.
منابع مشابه
KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer
APC (80-90%) and K-Ras (40-50%) mutations frequently occur in human colorectal cancer (CRC) and these mutations cooperatively accelerate tumorigenesis including metastasis. In addition, both β-catenin and Ras levels are highly increased in CRC, especially in metastatic CRC (mCRC). Therefore, targeting both the Wnt/β-catenin and Ras pathways could be an ideal therapeutic approach for treating mC...
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UNLABELLED PURPOSE AND STUDY DESIGN: Recent studies have shown that beta-catenin translocated into the cell nucleus functions like an oncogene. Accumulating evidence suggests that activation of the beta-catenin oncogenic signaling cascade along with its twin, the K-ras cascade, may exert syngeneic or synergistic effects on tumor development and progression. In the study reported here, we analyz...
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ژورنال
عنوان ژورنال: Organoid (Online)
سال: 2023
ISSN: ['2765-205X']
DOI: https://doi.org/10.51335/organoid.2023.3.e4